RNA-seq experiment of developing mouse forelimbs, comparing Bcl9/9l mutant with control littermates

Forelimbs were manually dissected from three individual Bcl9/9l-deltaHD1/deltaHD2 mutants and three control littermates, at 10.5 days post coitum. BCL9 and BCL9L are paralogous beta-catenin cofactors involved in the transcriptional machinery of Wnt target genes.于交配后10.5天，从3只Bcl9/9l ΔHD1/ΔHD2突变体与3只同窝对照小鼠中手动解剖分离前肢。BCL9与BCL9L为旁系同源的β-连环蛋白（β-catenin）辅因子，参与Wnt靶基因的转录调控机制。