9-methoxystrobilurin-G induced resistance
收藏NIAID Data Ecosystem2026-05-01 收录
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资源简介：
The natural product 9-methoxystrobilurin-G (9MG) from Favolaschia spp basidiomycetes is a potent and selective antimalarial. The mechanism of action of 9MG is unknown, but structurally related strobilurins from other fungal species are known to inhibit mitochondrial cytochrome b (CYTB) complex III. We induced 9MG resistance in Plasmodium falciparum laboratory strains 3D7 and Dd2 and identified mutated genes associated with resistance by genome sequencing.
创建时间：
2023-10-17
