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Single-nuclei RNA-Seq of mouse cardiomyocytes

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https://www.ncbi.nlm.nih.gov/sra/SRP434046
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资源简介:
Supporting material for the manuscript "Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy" (to appear in Nature Communications). Consists of single-nuclei RNA-Seq obtained from mouse heart contractile muscle cells (cardiomyocytes). Genotypes include wildtype, mutant in the RBM20 gene (P635L), as well as in vivo CRISPR-edited mutants using 3 different adeno-associated virus base editors - NRCH, NRCH8e, SpRY.
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2023-05-27
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