Enantioselective, Desymmetrizing Bromolactonization of Alkynes
收藏NIAID Data Ecosystem2026-03-07 收录
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Asymmetric bromolactonizations of alkynes are possible using a desymmetrization approach. The commercially available catalyst (DHQD)2PHAL promotes these cyclizations in combination with cheap NBS as a bromine source to give bromoenol lactones in high yield and with high enantioselectivity. The bromoenol lactone products, containing a tetrasubstituted alkene and a quaternary stereocenter, are valuable building blocks for synthetic chemistry.
创建时间：
2013-06-05
