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A comparative study of drug screening results based on organoid technology and clinical guideline recommendations in colorectal cancer liver metastasis

NIAID Data Ecosystem2026-03-14 收录

类器官药物筛选

结直肠癌肝转移治疗

数据链接：

https://www.omicsdi.org/dataset/ecrin-mdr-crc/84968 数据链接链接失效反馈

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Interventions: test group:Drugs based on organoid drug screening results;control group:Standard second-line drugs Primary outcome(s): ORR Study Design: Parallel

应用场景：

创建时间：

2023-03-15

结直肠癌肝转移治疗

肿瘤临床试验

Interventions: Treatment is administered every 2 weeks until evidence of DLT, progression, unacceptable toxicity, patient refusal, or for a maximum of 2 cycles to assess the feasibility. (phase I) Tre

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Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver

结直肠癌肝转移治疗

肝动脉灌注化疗

Background: Many people with colorectal cancer get liver metastases. Standard treatment for this is a combination of chemotherapy drugs. Directing the chemotherapy to the liver may be effective. A dev

NIAID Data Ecosystem60

FORECAST 1. Feasibility of using Organoid Response to find Effective Treatments for patients with Colorectal cancer After failure of Standard Therapy

类器官药物筛选

转移性结直肠癌治疗

Interventions: This feasibility study involves the collection of fresh tumour tissue from patients with Metastatic Colorectal Cancer ( mCRC) for the purposes of establishing organoid model cultures.Pa

NIAID Data Ecosystem40

Image-based profiling identifies compound induced phenotypes in patient-derived organoids

类器官药物筛选

结直肠癌精准治疗

Patient derived organoids (PDOs) closely resemble individual tumor biology. They are thus promising models for drug discovery and precision medicine. Here, we describe high-throughput imaging and auto

NIAID Data Ecosystem60

Intra-arterial hepatic beads loaded with irinotecan (Debiri) with concomitant chemotherapy with FOLFOX in patients with colorectal cancer with unresectable liver metastases: a phase II multicenter study

结直肠癌肝转移治疗

生存率评估

Primary objectives: Taux de survie sans progression à 9 mois selon RECIST 1.1. Primary endpoints: Le critère de jugement principal sera d’évaluer la proportion de patients vivants sans progression (le

NIAID Data Ecosystem40

A comparative study of drug screening results based on organoid technology and clinical guideline recommendations in colorectal cancer liver metastasis

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