Lewy pathology induced molecular dysfunction

Probe_Data_Mouse.RDS- The pre-qc data for the mouse GeoMx experiment

Probe_Data_Hu.RDS- The probe data for the Human GeoMx experiment

ACA_Profile.csv- Reference matrix of Anterior Cingulate Area for deconvolution calculation

MOs_Profile.csv- Reference Matrix of Secondary Motor Cortex for deconvolution calculation

Profile_human_allreg.csv_profileMatrix- Human reference matrix for deconvolution claculation

Profile_Matrix_setup_Human- Code for Human Profile Matrix setup

Profile_Matrix_Setup_Mu- Code for Mouse profile matrix setup

Top_genesets_mu/hu- The top differential genesetsets in the mouse/human data

LAMDA_Signature_Mouse- Data for the LAMDA signature for Mouse. (Differentially epxressed genes between Aggregate bearing and Non-aggregate bearing neurons). Avilable as CSV and RDS. Use this to explore the LAMDA signature for your genes of interest

LAMDA_Signature_Human-Data for the LAMDA signature for Human. (Differentially epxressed genes between Aggregate bearing and Non-aggregate bearing neurons). Avilable as CSV and RDS. Use this to explore the LAMDA signature for your genes of interest

Anchors-3mon: Anchors for cosmx cell typing

asstats_3mon: stats for cosmx cell typing

cohort_3mon: cohort info for cosmx cell typing

pSyn_positive_cells: CSV identifying all psyn postive cells

seurat_object_3mon: Seurat object contianing all the CosMx data (Note: CosMx method does not use Fastq files)