Egger et al., Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates, Cell reports (2024)
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https://data.mendeley.com/datasets/zdb9ccrpm6
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Mendeley Data set containin all the raw data presented throughthout Egger et al., Cell reports (2024).
Egger et al. implement their previously proposed ATR/Chk1 activation model by dissociating the functions of ATR and Chk1. Using reverse genetics and optogenetics, they show that Chk1 is phosphorylated at the interface of TopBP1 biomolecular condensates, triggering cell cycle checkpoints and slowing down replication fork progression.
创建时间：
2024-03-12
