RNA-sequencing and bioinformatics analysis of long non-coding RNAs and mRNAs in the prefrontal cortex of mice following repeated social defeat stress

RNA-sequencing was used to screen all differentially expressed (DE) lncRNAs and mRNAs between the RSD and control groups. In mice experiencing RSD, 373 and 454 lncRNAs, along with 1142 and 654 mRNAs were significantly upregulated and downregulated, respectively.Available informatics evidence highlighted the likely role of synapse dysfunction and abnormal synaptic neurotransmission in these behaviors. Thus, our findings provide potential candidate biomarkers or intervention targets for chronic psychological stress-induced neuropsychiatric disorders. Total RNA obtained from prefrontal cortex of mice subjected to repeated social defeat stress compared to untreated control mice.