Examining Alzheimer's Disease Modifiable Risk Factors: Impact of Physical Activity and Diet on Neuroanatomy and Behaviour in Mice

Dementia, a global public health challenge, is significantly influenced by lifestyle factors such as obesity. Despite the growing body of literature, the effects of obesity and intervention strategies on the brain remain largely unexplored. The present study aimed to investigate the effects of three intervention strategies —physical activity, low-fat diet, and the combination of both— in the 3xTgAD mice, and their wild-type (WT) counterparts, both fed a high-fat diet. We hypothesized that interventions would mitigate the effects of the high-fat diet on weight, behavior, and brain anatomy on 3xTgAD and WT mice. We collected longitudinal weight measurements, and T1-weighted (T1-w) magnetic resonance images (MRI) at two, four, and six months of age. Additionally, we performed memory tests (Morris water maze and novel object recognition tests) after the last MRI scan.

In this dataset you will find:

Scans in the DICOM format in the folder DICOM_files

longitudinal weight measurements from 2 months on in weight.csv

Behavioral data (Morris Water Maze in MWM_analysis.csv and Novel Object Recognition test in NOR_analysis.csv file)

Demographic data in demographics.csv file

Mice IDs in IDs.csv

Information regarding mice attrition in IDs.pdf

Quality Control data per timepoint in QC.csv