SARS-CoV-2 RBD Mutation Constellations (G339D, S375F, E484A, Q493R, L452R): Insights from Historical Data on Monoclonal Antibody Class 3 Escape Risk Measured from 2021 - 2023 Data

This dataset contains historical sars-cov-2 sequences that present 5 mutation constellations each in a given sequence. This may suggest that several mAbs are at risk of obsolesence which may or may not include Class-3 mAb The representative mAbs that may or may not be affected by this specific constellation such as "G339D, S375F, E484A, Q493R, L452R" may or may not include S309 / Sotrovimab, REGN10987 (Imdevimab), LY-CoV1404 (Bebtelovimab), ADG-20 (Adintrevimab), BRII-196 / AZD1061 (Cilgavimab). Further study may or may not suggest escape from these mAbs. ================================================================================ PROGRESSIVE CONSTELLATION SUMMARY (G339D + S375F + E484A + Q493R + L452R)================================================================================ FILE: constellation_1mut.csv-------------------------------------------------- Total unique sequences: 7,854,181 Top 10 sequences: 1. USA/CA-LACPHL-AF03923/2021 → Location: USA | Year: 2021 | Accession: 2021 2. USA/CA-CDC-FG-153775/2021 → Location: USA | Year: 2021 | Accession: 2021 3. USA/PA-BOL-M21128099/2021 → Location: USA | Year: 2021 | Accession: 2021 4. USA/CA-CDC-FG-153938/2021 → Location: USA | Year: 2021 | Accession: 2021 5. USA/FL-CDC-FG-023410/2021 → Location: USA | Year: 2021 | Accession: 2021 6. USA/MS-MSPHL-0575/2021 → Location: USA | Year: 2021 | Accession: 2021 7. USA/GA-GPHL-2326/2021 → Location: USA | Year: 2021 | Accession: 2021 8. USA/CEPH0000012663/2021 → Location: USA | Year: 2021 | Accession: 2021 9. USA/JW3282/2021 → Location: USA | Year: 2021 | Accession: 2021 10. USA/JW3304/2021 → Location: USA | Year: 2021 | Accession: 2021 FILE: constellation_2mut.csv-------------------------------------------------- Total unique sequences: 4,492,055 Top 10 sequences: 1. USA/CA-CDPH-3000263406/2021 → Location: USA | Year: 2021 | Accession: 2021 2. Switzerland/ZG-ETHZ-672463/2021 → Location: Switzerland | Year: 2021 | Accession: 2021 3. England/PLYM-2921E1F/2021 → Location: England | Year: 2021 | Accession: 2021 4. Switzerland/SZ-ETHZ-34518318/2021 → Location: Switzerland | Year: 2021 | Accession: 2021 5. Japan/SZ-NIG-Y222405/2022 → Location: Japan | Year: 2022 | Accession: 2022 6. Japan/SZ-NIG-Y222415/2022 → Location: Japan | Year: 2022 | Accession: 2022 7. USA/CA-CDPH-FS48099895/2022 → Location: USA | Year: 2022 | Accession: 2022 8. USA/CA-CDPH-FS48102929/2022 → Location: USA | Year: 2022 | Accession: 2022 9. USA/CA-CDPH-FS27887057/2022 → Location: USA | Year: 2022 | Accession: 2022 10. USA/CA-CDPH-FS25390299/2022 → Location: USA | Year: 2022 | Accession: 2022 FILE: constellation_3mut.csv-------------------------------------------------- Total unique sequences: 3,835,494 Top 10 sequences: 1. Japan/SZ-NIG-Y222405/2022 → Location: Japan | Year: 2022 | Accession: 2022 2. Japan/SZ-NIG-Y222415/2022 → Location: Japan | Year: 2022 | Accession: 2022 3. USA/CA-CDPH-FS48099895/2022 → Location: USA | Year: 2022 | Accession: 2022 4. USA/CA-CDPH-FS48102929/2022 → Location: USA | Year: 2022 | Accession: 2022 5. USA/CA-CDPH-FS27887057/2022 → Location: USA | Year: 2022 | Accession: 2022 6. USA/CA-CDPH-FS25390299/2022 → Location: USA | Year: 2022 | Accession: 2022 7. USA/CA-CDPH-FS48101995/2022 → Location: USA | Year: 2022 | Accession: 2022 8. USA/CA-CDPH-FS48076159/2022 → Location: USA | Year: 2022 | Accession: 2022 9. USA/CA-CDPH-FS48102001/2022 → Location: USA | Year: 2022 | Accession: 2022 10. USA/CA-CDPH-FS48101831/2022 → Location: USA | Year: 2022 | Accession: 2022 FILE: constellation_4mut.csv-------------------------------------------------- Total unique sequences: 3,632,086 Top 10 sequences: 1. Japan/SZ-NIG-Y222405/2022 → Location: Japan | Year: 2022 | Accession: 2022 2. Japan/SZ-NIG-Y222415/2022 → Location: Japan | Year: 2022 | Accession: 2022 3. USA/CA-CDPH-FS48099895/2022 → Location: USA | Year: 2022 | Accession: 2022 4. USA/CA-CDPH-FS48102929/2022 → Location: USA | Year: 2022 | Accession: 2022 5. USA/CA-CDPH-FS27887057/2022 → Location: USA | Year: 2022 | Accession: 2022 6. USA/CA-CDPH-FS25390299/2022 → Location: USA | Year: 2022 | Accession: 2022 7. USA/CA-CDPH-FS48101995/2022 → Location: USA | Year: 2022 | Accession: 2022 8. USA/CA-CDPH-FS48076159/2022 → Location: USA | Year: 2022 | Accession: 2022 9. USA/CA-CDPH-FS48102001/2022 → Location: USA | Year: 2022 | Accession: 2022 10. USA/CA-CDPH-FS48101831/2022 → Location: USA | Year: 2022 | Accession: 2022 FILE: constellation_5mut.csv-------------------------------------------------- Total unique sequences: 3,056 Top 10 sequences: 1. USA/AL-CDC-STM-6H6GXAJ83/2022 → Location: USA | Year: 2022 | Accession: 2022 2. OY222177 → Location: Unknown | Year: Unknown | Accession: OY222177 3. NZL/22CH5172/2022 → Location: NZL | Year: 2022 | Accession: 2022 4. OZ188816 → Location: Unknown | Year: Unknown | Accession: OZ188816 5. KEN/SS5217/2021 → Location: KEN | Year: 2021 | Accession: 2021 6. USA/CA-CDC-FG-286379/2022 → Location: USA | Year: 2022 | Accession: 2022 7. OX906942 → Location: Unknown | Year: Unknown | Accession: OX906942 8. OY138144 → Location: Unknown | Year: Unknown | Accession: OY138144 9. England/ALDP-2EB3DE3/2021 → Location: England | Year: 2021 | Accession: 2021 10. England/LSPA-2FC7176/2021 → Location: England | Year: 2021 | Accession: 2021 Summary complete. -------------------------------------------------- Any Queries / Critiques / Collaboration welcomed E-Mail: [e-mail]