Protein Common Interface Database

Protein Common Interface Database (ProtCID) contains comprehensive, PDB-wide structural information on the interactions of proteins and individual protein domains with other molecules, including four types of interactions: chain interfaces, Pfam domain interfaces, Pfam-peptide interfaces and Pfam-ligand/nucleic acids interactions. Its main goal is to identify and cluster homodimeric and heterodimeric interfaces observed in multiple crystal forms of homologous proteins, and interactions of peptide and ligands in homologous proteins.

蛋白质通用交互界面数据库（Protein Common Interface Database，ProtCID）涵盖了覆盖蛋白质数据银行（Protein Data Bank，PDB）全库的全面结构信息，涉及蛋白质、独立蛋白质结构域与其他分子之间的交互作用，包含四类交互类型：蛋白质链交互界面、蛋白质家族数据库（Pfam）结构域交互界面、Pfam-肽段交互界面以及Pfam-配体/核酸交互界面。该数据库的核心目标是识别并聚类同源蛋白质多种晶型中出现的同二聚体与异二聚体交互界面，以及同源蛋白质中的肽段与配体交互作用。