HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 6

HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 6 Descriptor: 4-(aminomethyl)-2-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one, Mitogen-activated protein kinase kinase kinase kinase 1 Authors: Johnson, E, Mc Tigue, M. Deposit date: 2024-08-05 Release date: 2024-12-18 Last modified: 2025-01-08 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer. J.Med.Chem., 67, 2024