Indole Diterpenoid Synthetic Studies. The Total Synthesis of (+)-Nodulisporic Acid F

A stereocontrolled total synthesis of (+)-nodulisporic acid F, the simplest member of a family of novel ectoparasiticidal agents, has been
achieved. Highlights of the effective modular synthetic strategy include anionic union of a tricyclic lactone with o-toluidine via our 2-substituted
indole synthetic protocol, an optimized C-ring construction protocol, and a late-stage installation of the α,β-unsaturated carboxylic acid side
chain via the B-alkyl Suzuki−Miyaura cross-coupling tactic.