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A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

ChEBI2015-03-04 更新2026-07-21 收录

CRISPR-Cas9脱靶

基因组编辑特异性

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-61099 数据链接链接失效反馈

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资源简介：

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

应用场景：

创建时间：

2015-03-04

CRISPR-Cas9脱靶

DNA断裂检测

We identified robust cleavage by non-canonically-targeted SpCas9 that target protospacer with a few bases from the canonical NGG PAM in biochemistry assay. To determine whether this spaced SpCas9 clea

NIAID Data Ecosystem80

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease

CRISPR-Cas9脱靶

基因编辑安全性

RNA-guided genome editing with the CRISPR-Cas9 system has great potential for basic and clinical research, but the determinants of targeting specificity and the extent of off-target cleavage remain in

NIAID Data Ecosystem50

Molecular Evidence of RNA Editing in Bombyx Chemosensory Protein Family

昆虫化学感应

基因组编辑特异性

Chemosensory proteins (CSPs) are small scavenger proteins that are mainly known as transporters of pheromone/odor molecules at the periphery of sensory neurons in the insect antennae and in the produc

NIAID Data Ecosystem50

AgxtQ84X rat model

CRISPR-Cas9脱靶

大鼠基因

The off target NGS data of spCas9 targeting the rat Agxt-Q84X site

NIAID Data Ecosystem80

Data production and mapping results for the three samples used.

MHC主要组织相容性复合体

基因组编辑特异性

Target regions here refer to contiguous MHC regions, rather than to the region actually covered by the designed probes. Capture specificity is defined as the percentage of uniquely mapped reads aligni

NIAID Data Ecosystem50

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

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