Gene expression of Dcir-/- osteoclasts induced by M-CSF and RANKL
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE223429
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Purpose: DCIR is an inhibitory type of C-type lectin receptor that regulates osteoclast (OC) formation and functions. This study aimed to find the genes of OCs that could be regulated through DCIR. Method: Bone marrow cells from WT and Dcir-/- mice were cultured in M-CSF for 2 days and the the cells were further cultured in M-CSF and RANKL. RNA profiles were generated by deep sequencing, in triplicate, using Illumina NovaSeq. Results: We detected xxx gense that were higher expression in Dcir-/- OCs, compared with WT OCs, with a fold change ≥1.5 and p value <0.05. Conclusion: Our data showed that Dcir deficiency in OCs changed the gene expression pattern, compared to WT OCs, which are induced by M-CSF and RANKL. mRNA profiles of WT and Dcir-/- osteoclasts for 2 days culture aftre RANKL stimulation
创建时间：
2023-06-07
