Regenerating axolotl retinas regrow diverse cell types with modulation by Notch signaling and reconnect to the brain

We examined uninjured and regenerating axolotl salamander retinas, including their transcriptional profile. We report that at 27 days after a retinectomy (early-mid regeneration), regenerating axolotl retinas exhibit downregulation of genes associated with neuronal networks but upregulation of genes associated with angiogenesis and the extracellular matrix. We also report differential expression of two Notch pathway effector genes, Hes1 and Hes5. Overall design: RNA profiles of uninjured and regenerating (27 dpi) axolotl salamander retinas