Studying the System-Level Involvement of MicroRNAs in Parkinson's Disease

BackgroundParkinson's Disease (PD) is a progressive neurologic disorder that affects movement and balance. Recent studies have revealed the importance of microRNA (miR) in PD. However, the detailed role of miR and its regulation by Transcription Factor (TF) remain unexplored. In this work for the first time we have studied TF-miR-mRNA regulatory network as well as miR co-expression network in PD.ResultWe compared the 204 differentially expressed miRs from microarray data with 73 PD related miRs obtained from literature, Human MicroRNA Disease Database and found a significant overlap of 47 PD related miRs (p-valueConclusionOur study identified 23 novel miR markers which can open up new avenues for future studies and shed lights on potential therapeutic targets for PD.