S1 Table -

A: Summary of reduction and compression of E.coli iJO1366 model. First a singleton reduction was realized where blocked reactions and singleton metabolites were removed, and found new irreversibilities were added; then the model was compressed by lumping linear pathways (in S1 Table). B: Summary of reduction and compression of Recon 2.2 model. First a singleton reduction was realized where blocked reactions and singleton metabolites were removed, and found new irreversibilities were added; then the model was compressed by lumping linear pathways (in S1 Table). C: Topologically independent modules of iJO1366. The 294 structural reversible reactions were grouped in 103 modules (in S1 Table). D: Correlation in gene expression between structurally reversible reactions of distance 2 of the iJO1366 model (in S1 Table) E: Effect of removing antiporter reactions. Flux variability analysis shows that range fluxes do not differ between full [vminF,vmaxF] and reduced [vminR,vmaxR] model (in S1 Table). F: Topologically independent modules of Recon 2.2. The remaining 1,168 structural reversible reactions, after removal of antiporter reactions, were grouped in 321 modules (in S1 Table). G: correlation in gene expression between structurally reversible reactions of distance 2 of the Recon 2.2 model (in S1 Table) H: Directionality constraints used for E.coli iJO1366 model (in S1 Table) I: Directionality constraints used for Recon 2.2 model (in S1 Table) J: Currency metabolites that were removed from reactions (in S1 Table). Table K: Reversible reactions with and without currency metabolites of E.coli iJO1366 model (in S1 Table). Table L: Reversible reactions with and without currency metabolites of Recon 2.2 model (in S1 Table) Table M: Cliques distribution for different correlation thresholds in the largest metabolic modules of the iJO1866 model (in S1 Table).
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