Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis
收藏NIAID Data Ecosystem2026-03-11 收录
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Sequencing of KRAS amplicons derived from human pancreatic tissue via laser capture microdissection
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创建时间：
2020-01-02
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An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [Set2]
Damaged tissues have increased risk of cancer development through poorly understood mechanisms. In the pancreas, tissue damage collaborates with activating mutations in the Kras oncogene to dramatical
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Mutant Kras co-opts a progenitor-derived enhancer network to initiate pancreatic tumorigenesis [RNA-seq]
Oncogenes are highly specific in the cells they can transform, although the molecular basis for this is poorly understood. Inflammation often promotes tumorigenesis, and in the pancreas it promotes ce
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Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling [single-cell RNA-seq]. Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling [single-cell RNA-seq]
We performed Smart-seq2 scRNAseq on 156 pancreatic tuft cells . We also profiled FACS sorted EpCAM+;CD45+ immune cells and EpCAM-;CD45- non-immune stroma cells from from 3 caerulein-treated KC and 2 c
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Additional file 1 of NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
Additional file 1. GSEA genesets from GO_BP, GO_MF and KEGG databases enriched in KC vs KNeC lesions and KNeC vs KC lesions.
Figshare2024-09-12 更新70
Additional file 34 of Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity
Additional file 34: Table S9. Raw data obtained from cBioPortal for all breast cancer patients separated by KRAS amplification/mutation status. Redundant patient samples have not been removed.
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