Clinical, pathologic and molecular characteristics of colon cancer cases according to CIMP status.

(%) indicates the proportion of cases with a specific clinical feature within each MSI/CIMP subtype.��Proximal colon includes cecum to transverse colon, and distal colon includes splenic flexure to sigmoid colon.*p53 and ��-catenin status was determined by immunohistochemistry. Active ��-catenin was defined as ��-catenin score ��3, where the ��-catenin score was the sum of nuclear (0, 1+ or 2+), cytoplasmic (0, 1+ or 2+) and membrane (0 or 1+ if expression is lost) scores as originally described by Jass et al.[35].#t-test assuming unequal variances.CIMP, CpG island methylator phenotype; LINE-1, long interspersed nucleotide element-1; MSI, microsatellite instability; SD, standard deviation.