HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 13
收藏Protein Data Bank Japan2025-01-08 更新2026-04-19 收录
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https://pdbj.org/mine/summary/9czw
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资源简介：
HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 13 Descriptor: 6-(dimethylamino)-4-[(methylamino)methyl]-2-[6-(4-propyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl]-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one, Mitogen-activated protein kinase kinase kinase kinase 1 Authors: Johnson, E, Mc Tigue, M. Deposit date: 2024-08-05 Release date: 2024-12-18 Last modified: 2025-01-08 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer. J.Med.Chem., 67, 2024
创建时间：
2024-08-05
