Haplotype association analysis of F11 hit SNPs with VT risk in a sample of 1,542 VT cases and 1,110 controls.

F11 haplotypes were more strongly associated with VT (p = 1.05 10−12) than single SNP alone (best p-value = 1.09 10−9) and the association was likely due to two common haplotypes, ATTC and GCCA, differing at all studied sites (“yin-yang” haplotypes), the former being associated with increased risk of VT, the latter with decreased risk. Compared to the GTTC haplotype, the ATTC haplotype was associated with an increased risk of VT (OR = 1.218 [1.048–1.416], p = 0.0099 while the GCCA haplotype was associated with a decreased risk of the disease (OR = 0.493 [0.391–0.623], p = 3.39 10−9).