Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats II

RNA-Seq was used in an attempt to identify candidate genes regulating metabolic and physiological traits Overall design: Physiological mapping identified physiological QTLs (pQTLs) affecting metabolic and physiological traits. Genes with cis-eQTLs mapped within each pQTL may may drive the physiological traits in a causal manner; and was assessed by mediation analysis.