Complexome profiling of human induced pluripotent stem cells cultured during normoxic versus hypoxic conditions

Human induced pluripotent stem cells (hiPSCs) have become an invaluable tool for studying molecular disease mechanisms on a human genetic background. They can be differentiated into different cell types, including cardiac myocytes. Here, we studied the remodeling of mitochondrial protein complexes of hiPSCs cultured under hypoxic versus normoxic conditions.