Longitudinal analyses of APOE genotype and radiographic score, CRP and ESR as dependent variables in the EURIDISS cohort.

SHS, CRP and ESR have all been log-transformed.¥Models were adjusted for: a = time, b = time, age, sex, disease duration, ACPA and DMARD treatment (ever/never).¤Model B with SHS outcome was also adjusted for CRP. For the models investigating CRP or ESR n = 207, while for joint damage (SHS) n = 176. Patients with genotype ε2/ε4 were omitted from the analyses.£In the analyses where APOE genotype is a categorical factor, ε3/ε3 is the reference group.$In the linear analyses (APOE linear), ε2, ε3/ε3, and ε4 are coded 0, 1 and 2 respectively.§Overall p-value.*P-values corrected for multiple testing using Sidaks’ adjustment.