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FactorForge source-profile benchmark pack (v2)

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Zenodo2026-06-18 更新2026-06-21 收录
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Reproducible in-silico benchmark of synonymous CDS design for Nicotiana benthamiana under four explicitly versioned codon usage source profiles: a historical packaged reference, a QLD183 v103 CDS-derived profile, and two NbeV1.1 CDS-derived profiles (all annotated CDS; high-confidence subset). Each profile was injected into both the design and scoring paths so that the design and scoring codon tables are identical per run. Seven methods were evaluated on N = 49,257 sequences (seed 320, scoring_contract v1.1): a native reference, random synonymous, single-objective greedy CAI, and four FactorForge strategies. The pack contains the codon usage tables, build manifests and filtering statistics, per-profile frozen summaries, aggregated comparisons, a Profile A reproduction-integrity diff, the profile build script, and SHA-256 checksums. Computational CAI and GC values are source-profile-specific computational coordinates; no wet-lab, yield, expression, or clinical performance is claimed, and no codon reference is asserted to be biologically superior.

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Zenodo
创建时间:
2026-06-18
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