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Brown adipose tissue monocytes support tissue expansion

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE177635
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We report that monocytes contribute to the maintenance of BAT macrophages in a dynamic manner at steady state, and allow tissue remodelling during BAT expansion. Using scRNA-Seq, we explored monocyte and macrophage diversity in BAT at steady state and during BAT expansion. Brown adipose tissue CD45+ cells from AdipoQcre-ERT2 ATGLfl/fl and control mice were cell sorted and analyzed by single-cell RNA sequencing.
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2021-09-29
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