The influence of microplastic particles on the effectiveness of electrochemotherapy in breast cancer cells

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<span lang="EN">Microplastic
particles (MPs) (ranging in diameter from 0.1 μm to 5 mm) pose a significant
threat to the natural environment. They are created by human activity during
the production of certain products and the degradation of plastics. Breast
cancer is the most common form of malignancy and the second leading cause of
cancer-related deaths in women. MPs can also induce inflammation and oxidative
stress in tissues, which may be associated with an increased risk of developing
cancers, including breast cancer. Electrochemotherapy (ECT) is a procedure that
combines the administration of chemotherapy drugs (doxorubicin, daunorubicin)
with precisely calibrated electrical pulses for cell membrane electroporation
(EP). This method is currently used clinically in over 140 centers in Europe
and demonstrates very high efficacy and minimal invasiveness. It has been
incorporated into the standard treatment of many different types of cancer,
including breast cancer. An interesting question is to investigate the impact
of MPs on the effectiveness of electrochemotherapy in the treatment of breast
cancer cells?</span></p>

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