The histone variant H2A.Z is central to early embryonic development, determining transcriptional competency through chromatin regulation of gene promoters and enhancers. In addition to genic loci, we

NIAID Data Ecosystem40

The Dlk1-Dio3 noncoding RNA cluster coordinately regulates mitochondrial respiration and chromatin structure to establish proper cell state for muscle differentiation. The Dlk1-Dio3 noncoding RNA cluster coordinately regulates mitochondrial respiration and chromatin structure to establish proper cell state for muscle differentiation

肌肉分化分子机制

染色质调控

To investigate the collective role of the Dlk1-Dio3 ncRNA cluster in myogenesis, we developed two stable CRISPR-Cas9 gene-edited C2C12 skeletal muscle cell lines, Meg3-proximal cis-acting sequence (Me

NIAID Data Ecosystem70

A multiscale 3D chromatin architecture that controls development of the humoral immune system is assembled by IKAROS [RNA-seq LpreB]

染色质调控

血细胞发育转录组学

A generic level of chromatin organization generated by the interplay between cohesin and CTCF suffices to limit promiscuous interactions between regulatory elements, but a lineage-specific assembly of

NIAID Data Ecosystem40

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

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