Multi-Hit Environmental Matrix and Saturation Index Model of Skin Carcinogenesis

This record contains the supplementary materials for the conceptual and mathematical framework titled Multi Hit Environmental Matrix and Saturation Index Model of Skin Carcinogenesis. The materials provide extended methods, mathematical derivations, parameter tables, simulation documentation, reproducibility information, and preregistered experimental protocols that support the main manuscript. The supplement includes detailed derivations of the Membrane Peroxidation Index and the Photo Oxidative Threshold, along with parameter priors, worked numeric examples, and guidance for converting lipidomics data into model inputs. It also contains full simulation methods, sensitivity analysis procedures, and code templates for generating MPI values, POT curves, and stochastic incidence simulations. The record provides preregistered protocols for planned keratinocyte and animal pilot studies, a reproducibility checklist, a literature search strategy, and documentation for the use of public datasets in model calibration. A one page policy brief is included for non technical stakeholders, outlining cautious messaging and translational considerations. All files in this Zenodo record are intended to support transparency, reproducibility, and future empirical validation of the conceptual model. The main preprint will be released separately through an appropriate preprint server.