TSNAdb

Tumor-specific neoantigens play important roles in tumor immunotherapy. How to predict neoantigens accurately and efficiently has attracted much attention. TSNAD is the first one-stop neoantigen prediction tool from next-generation sequencing data, and TSNAdb provides both predicted and validated neoantigens based on pan-cancer immunogenomics analyses. In this chapter, we describe the usage of TSNAD and TSNAdb for the clinical application of neoantigens.肿瘤特异性新抗原（tumor-specific neoantigens）在肿瘤免疫治疗中发挥着关键作用。如何精准高效地预测新抗原，已成为该领域广受关注的研究热点。TSNAD是首款基于下一代测序（next-generation sequencing）数据的一站式新抗原预测工具，而TSNAdb则依托泛癌免疫基因组学（pan-cancer immunogenomics）分析，提供预测所得及已验证的新抗原数据。本章将阐述TSNAD与TSNAdb在新抗原临床应用中的使用方法。

搜集汇总

背景与挑战

背景概述

TSNAdb是一个专注于肿瘤特异性新抗原的数据集，基于泛癌免疫组学分析提供预测和验证的新抗原信息。它关联TSNAD v2.0软件，该软件作为集成工具，能从肿瘤-正常配对的WGS/WES数据中检测新抗原，并支持从突变数据和HLA等位基因进行预测。