Associations with CIMP-high in proximal and distal colorectal cancers.

Each multivariate logistic regression model assesses a variable of interest (stratified by tumor location in a given model), adjusting for all of the above remaining variables. An interaction was assessed by the likelihood ratio test that compares a model including a cross product term (of the location variable and another variable of interest) with a model excluding it. *β-catenin activation is defined as β-catenin score ≥3, where the β-catenin score is the sum of nuclear (0, 1+ or 2+), cytoplasmic (0, 1+ or 2+) and membrane (0 or 1+) scores as originally described by Jass et al.[35]. ∧Proximal colon includes cecum to transverse colon, and distal colon includes splenic flexure to rectum. #Because there was no CIMP-high β-catenin-active tumors in distal colon, stable p for interaction and 95% CI for OR could not be estimated. CI, confidence interval; CIMP, CpG island methylator phenotype; LINE-1, long interspersed nucleotide element-1; MSI, microsatellite instability; OR, odds ratio.