Ewing sarcoma single-cell transcriptome analysis reveals functionally impaired antigen-presenting cells

Novel therapeutic strategies are urgently needed for high-risk Ewing sarcoma (EwS) patients and for the reduction of severe side-effects for all patients. Immunotherapy may fill this need, but its successful application has been hampered by a lack of knowledge on the composition and function of the EwS immune microenvironment. Here, we explore the immune microenvironment of EwS, by single-cell RNA sequencing of 18 EwS primary tissue samples. Eighteen Ewing sarcoma primary tissue samples from 11 patients were single-cell RNA sequenced using the CEL-seq2 method ------------------------ Authors state "Raw data are unavailable due to patient privacy concerns."