RUNX3 promotes the development of MDS via suppressing expression level of Runx1 and enhancing activation of Myc pathway in the absence of Tet2.
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Analysis of Hematopoietic stem and progenitor cells (HSPCs) expressing Runx3. The RUNX transcription factors have a critical role in normal and malignant hematopoiesis including myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS). Results provide insight into the role of Runx3 in the development of MDS.
创建时间：
2020-02-27
