Cryo-EM structure of human Nav1.6 in complex with Cn2

Cryo-EM structure of human Nav1.6 in complex with Cn2 Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... Authors: Fan, X, Huang, J, Yan, N. Deposit date: 2026-04-06 Release date: 2026-05-20 Last modified: 2026-08-19 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Diverse binding poses of agonistic neurotoxins on human Na v 1.6. Nature, 656, 2026