AUF1 modulates senescence via regulating transcription and alternative splicing of immune response genes in auditory hair cells

Conclusion: To our knowledge, this is the first investigation of its kind that has described the transcriptome-wide analysis of AUF1-regulated expression and alternative splicing profiles and has demonstrated the possible mechanisms of AUF1 regulating immune response, apoptosis, and alternative splicing, which could aid future researches on cellular biology and contribute to the deciphering of the aging process and presbycusis.研究结论：据我们所知，本研究是同类研究中首次针对AUF1调控的基因表达与可变剪接谱开展全转录组分析，并阐明了AUF1调控免疫应答、细胞凋亡及可变剪接的潜在分子机制。本研究可为后续细胞生物学相关研究提供助力，同时有助于解析衰老进程与老年性耳聋的发病机制。