SMR results for PCSK9 pleiotropic analyses.

Cohort: cohort of the eQTL study, probeID: ID of the probe used in respective cohorts for gene of interest, ProbeChr: chromosome of the probe used in respective cohorts for gene of interest, Gene: gene analysed, Probe bp: base pair position of the probe bp used in respective cohorts for gene of interest, topSNP: eQTL/SNP with lowest p-value for gene-tissue combination, topSNP chr: chromosome of the topSNP, topSNP bp: base pair position of the topSNP, A1: effect allele of topSNP, A2: other allele of topSNP, Freq: allele frequency for A1, b GWAS: beta for topSNP in the GWAS study, se GWAS: SE for topSNP in the GWAS study, p GWAS: P-value for topSNP in the GWAS study, b eQTL: beta for topSNP in the eQTL cohort, se eQTL: SE for topSNP in the eQTL cohort, p eQTL: P-value for topSNP in the eQTL cohort, b SMR: beta for SMR analysis using the topSNP only, se SMR: SE for SMR analysis using the topSNP only, p SMR: P-value for SMR analysis using the topSNP only, p SMR multi: P-value for SMR analysis using all significant independent SNPs, p HEIDI: P-value for the HEIDI analysis. Blank if test wasn’t conducted, nsnp HEIDI: number of SNPs used for HEIDI analysis. Blank if less than 3 SNPs—analysis was not conducted, Tissue: Tissue type used for eQTL summary statistics, Outcome: Traits analysed. (XLSX)