Expression data from MZ Twins discordant for concussion

Researchers have long relied on gene expression changes identified in animal models to develop targeted therapy for traumatic brain injury (TBI), but so far these therapies have not proved effective in human trials. While these pre-clinical models have provided valuable mechanistic insights, they might not reflect the unique pathophysiology of concussion in humans. Identifying important and potentially modifiable gene expression changes in humans diagnosed with TBI can help facilitate effective therapies. The objective of the current study was to identify important and potentially novel differences in mRNA expression among this single pair of MZ twins discordant for sport-related concussion (SRC). 19-year-old female MZ twins had baseline (T0) preseason peripheral blood drawn. One twin sustained an SRC, afterwards both twins had peripheral blood drawn at 6 hours (T1) and 7 days post-injury (T2). Cognitive performance and postural stability were assessed at T0, at 3-days post-injury, and at T2.