Copanlisib modulates HAIR-M transcriptome
收藏NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE137325
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资源简介：
Exposure to copanlisib in an MZL cell line heavily affected the lymphoma cell transcriptome, downregulating the MYC transcriptional program, alongside NFkB signaling, mTOR signaling, glycolysis, genes that are essential for cancer cells and also molecules important for immune escape (CD274, PDCD1, CSF1, TIMP1), suggesting the exploration of combinations including copanlisib and immune-checkpoint modulators. To assess the effects of copanlisib on the transcriptome, we exposed the MZL cell line HAIR-M to DMSO or copanlisib (5nM, for 4, 8 and 12 h) in triplicates.
创建时间：
2020-03-16
