Oxidant-Free Direct Coupling of Internal Alkynes and 2-Alkylpyridine via Double C−H Activations by Alkylhafnium Complexes
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资源简介：
We have developed a novel oxidant-free direct cross-coupling reaction of 2,6-lutidine and internal alkynes leading to five-membered carbocyclic compounds mediated by nonmetallocene cationic hafnium alkyl complexes. Mechanistic studies of the coupling reaction showed that the reaction begins with C(sp3)−H bond activation via σ-bond metathesis, after which the coordinatively unsaturated hafnium center mediates further insertion, migration, and β-H elimination reactions to give five-membered carbocycles from readily available substrates.
创建时间：
2011-02-02
