Combined pdf with Figs. A—K and Tables A—D.

Fig. A, Impact of serum on HSPC proliferation and immunophenotype during co-culture with MSCs. Fig. B, Correlation of HSPC proliferation with blood parameters of serum samples. Fig. C, Detected miRNA numbers correlate with leukocyte count. Fig. D, Differential miRNA expression in serum before and after chemotherapy among patient subgroups. Fig. E, Gene ontology analysis of miRNA-320c targets. Fig. F, Inhibition of miRNA-320c activity enhances HSPC proliferation. Fig. G, Correlation of metabolite levels with patient’s leukocyte count. Fig. H, Correlation of metabolite levels with patient’s thrombocyte count. Fig. I, Correlation of metabolite levels with patient’s erythrocyte count. Fig. J, Correlation of metabolite levels with patient’s hemoglobin concentration. Fig. K, Effects of metabolites on HSPCs in co-culture with MSCs. Table A, Serum samples used as cell culture supplement. Table B, Serum samples used for miRNA profiling. Table C, Serum samples used for metabolomic profiling. Table D, Detailed patient treatment information. (PDF)