1H-NMR metabolomic data in pigs to improve the understanding of heat stress adaptation mechanisms

Heat stress is one of the main limiting performance factors in the pig industry, and its importance is expected to grow with the consequences of a warming climate. Different solutions to temper the influence of heat stress on the performance and well-being of pigs have been studied, and genetic selection appears as a potential solution. Genetic mechanisms behind heat tolerance are still poorly understood, but some differences between breeds and an interaction between genetics and environment have been shown. This study aims to use omics data to understand the metabolic pathways involved in heat stress adaptation. To achieve this, NMR metabolomic data from Longissimus dorsi muscle, liver, plasma, and urine were obtained in an experiment involving 36 pigs from 3 breeds slaughtered before (n=18) or after a 5-day exposure to 32°C (n=18). The animals were raised at the French Experimental Unit PTEA, INRAE, Petit-Bourg in Guadeloupe. 35 samples were available for analysis.