Lipid loci with multiple and population-specific signals in African Americans.

aLD (r2/D′) with SNP showing the strongest evidence of association at each locus.bβ: effect size from an additive model and corresponding to the effect allele, in the unit of mmol/L for HDL-C, LDL-C and natural log transformed TG.cP values of sequential conditional analyses, in which we added the SNP with the strongest evidence of association into the regression model as a covariate and tested for the next strongest SNP until the strongest SNP showed a conditional P value>10−4 and had no annotation suggesting potential function.dVariance explained was estimated based on PAGE samples (n = 5,593).eP values of initial association in East Asians and Europeans.fConditional analyses at LDL-C locus PCSK9 were restricted to 5,593 PAGE samples because SNPs rs67608943 (Y142X), rs72646508 (L253F) and rs11591147 (R46L) were not polymorphic in HyperGEN samples.