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Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis.. Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis.

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA421580
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By developing Akron-Seq, a novel approach that captures native 3' and 5' ends of capped and polyadenylated RNAs respectively, we show that canonical human mRNAs are subject to repeated, cotranslational, ribosome-phased, endonucleolytic cuts in a process that we term ribothrypsis. Overall design: Capturing native 3' ends of capped and 5' ends of polyadenylated mRNAs
创建时间:
2017-12-07
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