Clinical data of the patients.

All off and on medication motor scores were obtained using of the motor section of the UPDRS [48]. The UPDRS is a five-point scale, meaning that the scoring range for each item spans from “0" ( = normal) to “4" ( = maximal impairment). For example, speech can be assessed with item 18 using the following scores: “0" = normal; “1" = slight loss of expression, diction and/or volume; “2" = monotone, slurred but understandable (moderately impaired); “3" = marked impairment, difficult to understand; “4" = unintelligible. SD = Standard deviation.