Successful Clinical Response in Pneumonia Therapy (SCRIPT)

The goal of this study is to iteratively identify, validate and refine biomarkers to predict clinical failure, and identify novel targets for therapy beyond traditional antibiotics for patients with severe pneumonia requiring intubation, including severe community-acquired pneumonia (CAP), hospital-acquired pneumonia, and ventilator-associated pneumonia (HAP/VAP). We hypothesize that factors within the alveolar microenvironment in many patients with pneumonia prevent the active process of pneumonia resolution. Pneumonia - encompassing both CAP and HAP/VAP - accounts for nearly 80% of infection-related deaths in the United States. The COVID-19 pandemic further underscores the significant morbidity and mortality associated with severe pneumonia. Our U19 Systems Biology Center, Successful... (for more see dbGaP study page.)