Microglial-expressed Apoe does not modulate plaque pathogenesis

This dataset allows for the exploration of the effect of microglial-expressed Apoe knockout in a 5xFAD Alzheimer's Disease model. Mice hippocampi were sequenced in the following groups at 4 and 12 months of age: 1. Apoe(fl/fl) 2. Apoe(fl/fl) Csf1r-cre 3. Apoe(fl/fl) 5xFAD 4. Apoe(fl/fl) 5xFAD Csf1r-Cre. Microglial-expressed Apoe was knocked out of mice that are homozygous for Apoe(fl/fl) and hemizygous for Csf1r-cre. n=3-8 for each group本数据集可用于探究5xFAD阿尔茨海默病（Alzheimer's Disease, AD）模型中小胶质细胞表达的载脂蛋白E（Apoe）敲除的效应。实验选取4月龄与12月龄的小鼠海马体，按以下分组开展测序：1. Apoe(fl/fl)；2. Apoe(fl/fl) Csf1r-cre；3. Apoe(fl/fl) 5xFAD；4. Apoe(fl/fl) 5xFAD Csf1r-Cre。针对同时为Apoe(fl/fl)纯合子与Csf1r-cre半合子的小鼠，其小胶质细胞表达的Apoe已被敲除。每组样本量为3~8只。