Interaction of integrin alphaIIbbeta3 with von Willebrand factor

Integrin alphaIIbbeta3 (glycoprotein IIb-IIIa, GP IIb-IIIa) is one of the major platelet receptor that is involved in aggregation and adhesion of platelets. In resting stage alphaIIbbeta3 is inactive and does not interact with its ligands but upon activation or vascular injury it binds to the ECM protein von Willebrand factor (vWf) and stimulate the platelet aggregation.

整合素αIIbβ3（糖蛋白IIb-IIIa，GP IIb-IIIa）是血小板受体中的主要成分之一，参与血小板的聚集和粘附过程。在静息状态下，αIIbβ3处于非活性状态，不与其配体发生相互作用；然而，在激活或血管损伤的情况下，它将与血管外基质蛋白vWf（冯·维勒布兰德因子）结合，并刺激血小板聚集。