Top MixMAP and single SNP evidence for IBC array locus association with LDL-C in PennCAC.

For the 31585 SNPs in 2944 genes interrogated in PennCAC, MixMAP identifies loci in PennCAC that are not identified by single SNP analysis. Of these gene/loci, SNPs in reach genome wide significance in GLGC (SORT1 and LPA) and are also MixMAP significant in GLGC; is MixMAP significant but single SNP non-significant in GLGC (VPS13B), and 2 have animal model data supporting modulation of lipid metabolism (VPS13B and IL1R2). †No association with plasma lipids but implicated in Cohen syndrome in which truncal obesity is a feature; indicates corresponding gene detected and – indicates corresponding gene not detected; IBC array threshold (); Bonferroni correction based on the number of genes (); Based on published literature (see corresponding citations): A: human data; B: mouse/animal data; and C: cell biology.