Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

NIAID Data Ecosystem2026-03-12 收录

造血干细胞

癌细胞重编程

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE158797 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2021-08-27

Epigenetic Memory Underlies Cell Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells

造血干细胞

表观遗传学

Stem cells determine homeostasis and repair of many tissues and are increasingly recognized as functionally heterogeneous. To define the extent of and molecular basis for heterogeneity we overlaid fun

干细胞与再生医学数据中心2022-02-20 更新100

Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system. Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system

癌细胞重编程

癌症靶向治疗

Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p

NIAID Data Ecosystem60

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

造血干细胞

HOX基因表达

Class I homeobox (Hox) genes encode a major group of transcription factors controlling embryonic development and have been implicated in the continuing process of hematopoietic cell differentiation. T

PubMed Central1994-12-06 更新40

Prospective identification and lineage tracing of top-level hematopoietic stem cells that sustain adult hematopoiesis

造血干细胞鉴定

造血干细胞

Hematopoietic stem cells (HSC) sustain long-term reconstitution of hematopoiesis in primary transplantation recipients. Few HSC can serially reconstitute secondary recipients, and their identity and c

NIAID Data Ecosystem80

Total RNA sequencing for Mus musculus bone marrow lymphoid committed cell populations

细胞RNA测序

造血干细胞

MPP2, MPP3 and CLP populations were isolated by fluorescence-activated cell sorting (FACS) from the BM of B6 mice based on the surface expression of VCAM1, FLT3 and IL7Ra within LSK population. On a

NIAID Data Ecosystem40

Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

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